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KMID : 0359320010410030319
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Korean Journal of Veterinary Research
2001 Volume.41 No. 3 p.319 ~ p.325
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The regulaion of Mg2+ efflux by melatonin in perfused guinea pig hearts
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김진상/Kim, Jin Shang
장효진/육지혜/Chang, Hyo Jin/Youk, Ji Hea
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Abstract
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Several recent studies demonstrate that cAMP accumulation evokes marked changes in magnesium (Mg^2+) homeostasis. The goal of this study was to investigate the effect of melatonin, the principal hormone of the vertebral pineal gland, on Mg^2+ efflux induced by adrenergic drugs and cAMp analogues because melatonin inhibites adneylate cyclase (AC) and phospholipase C(PLC) in the hearts. The Mg^2+ content in the perfusate was significantly higher in the presence than in the absence of melatonin. The addition of forskolin, isoproterenol or dimaprit to perfused hearts induced a marked Mg^2+ efflux. These effluxes were not inhibited by melatonin. The Mg^2+ efflux could also be induced by phenylephrine, α_1 - adrenoceptor agonist. This phenylephrine-induced Mg^2+ efflux was inhibited by melatonin. In addtion, the phenylephrine-induced Mg^2+ efflux was potentiated by PMA, a protein kinase C(PKC) activator. This Mg^2+ efflux was inhibited by melatonin. In conclusion, these data suggest that melatonin regulates Mg^2+ homeostasis and the inhibitory effect of melatonin on α_1adrenoceptor-stimulated Mg^2+ efflux may occur through an inhibition of PLC pathway in perfused guinea pig hearts
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KEYWORD
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magnesium, melatonin, α1 - adrenoceptor, heart
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